According to Dr. Jean Dodds of Hemopet, researchers and veterinarians thus far cannot point to breed characteristics, age group, drug interactions or genetic mutations as contributing factors to the latest findings that prompted the FDA warning. In other words, the reported adverse reactions to Bravecto had nothing to do with whether or not a dog had MDR1. . As far as which flea and tick protection would be safest for a puppy, some of my top picks are Capstar (for instant relief, not necessarily long-term use), a natural oil spray like Natural Chemistry or Wondericide, or something not very harsh like Frontline Plus. enough to have 4 dogs like I do! . Dogs with normal MDR1 genes can usually tolerate oral dosages as high as 2,500 mcg/kg of body weight before signs of toxicity are seen, while dogs with two copies of the defective MDR1 gene can tolerate only up to 100 mcg/kg of oral ivermectin. Hi. Simparica starts killing fleas within 3 hours and ticks within 8 hours, and it keeps going strong for 35 days without losing effectiveness at the end of the month. I honestly didnt know they existed until I started researching more to answer your question. I was bummed to read its the safest since I dont want him to have it every again (a little off balance shortly after and salivating) but later he had an episode with fixed eyes, stuck in a strange position, stiff muscles, blind, he had a heart rate half of what it should have been and a head tremor. The rx I currently use on my dogs is serolaner (Simparica). It also helps to know your dogs MDR1 statuses, which can be checked through places like Paw Print Genetics. A mutation of this gene causes sensitivity to Ivermectin and a number of other drugs. (I googled veterinary pharmacists near me and found one locally, but Jacksonville is a huge city.) I just took her off Sentinel Flavor Tabs. Simparica may cause abnormal neurologic signs such as tremors, unsteadiness, and/or seizures. Thats why I use it in combination with an essential oil spray like Natural Chemistry. Dogs with the MDR1 genetic mutation can become very ill or die if given certain medications. Of all the products you mentioned, I would prefer to try K 9 Advantix since it both repels and kills. Thats what I plan to use in future, when my oldest dog reaches that point. Interceptor and Sentinel are safe for Border Collies. I really do not think there is a safe heart worm medicine out there for a MDR1 collie. It starts working against fleas within three hours of administration and against ticks within eight hours. I know youre very particular about the genetic health of your Collies, and I admire your breeding program. These can come in a few different forms: monthly spot-on, a disposable collar, or a spray. Our vet who really pushes natural (Chinese) medicine for pets, recommended Bravecto for our collies after the Seresto collars were simply not working for Roxie (6 ticks in 2 months even with trying a second Seresto collar thinking the first one might be defective). If you have more than one dog and they engage in mutual grooming, you should probably pick a different parasite preventive. Thanks much for the info before I bought anything! Due to this fact, Pet Place warns: Happy to help! The agency is asking the manufacturers to make the changes to the product labeling in order to provide veterinarians and pet owners with the information they need to make treatment decisions for each pet on an individual basis.. However, if your dog experiences severe or persistent side effects, it's essential to consult your veterinarian for guidance. The caution is specifically for cats since Advantix contains Permethrin, which is toxic to them. Low or high blood sugar. Personally I use Frontline Plus and supplement weekly with a Natural Chemistry spray as a repellent, but I understand that might not be ideal for everyone depending on their situations. Any thoughts on either of these? March 1, 2022 Learn what medications may be dangerous for your dog with the MDRI genetic mutation. Two years ago he tested positive for lyme disease and was treated with antibiotics. But frankly we're baffled that they've approved it. I actually ended up choosing Interceptor Plus along with Credelio after looking at your research and getting some advice from fellow Aussie owners. Best of luck with your girl! I just had my vet mention the mdr1 gene today in passing. Shes been a red hot mess and Im not convinced Simparica isnt the cause(stomach issues, hyper activity(I raised a border so ready for energy but this is frenetic) and not sleeping more then 30- 40 minutes at a time. (Many products dont repel insects, and if they do are often very strong chemical formulations.). We do eat it! Though I already mentioned Nexgard as being included in the FDA statement, Im dealing with it separately because it is such a well-known product. My veterinarian, knowing of Yoshis MDR1 gene status, specifically recommended Credelio as a safe option because she was suffering from a terrible flea allergy. I like Frank so much that I had to give him his own story. If you have a dog you suspect has Giardia, it really is best to see a veterinarian. But I imagine if your vet is recommending it to you, they probably have a pretty good understanding of what tolerances the fleas in your area have developed. Based on my findings, Im not convinced of its superior safety. (The Environmental Protection Agency is responsible for approving external flea and tick products.) If you can, its always a good idea to consult with a vet who is knowledgeable about MDR1 and Collies. We have a rescue Aussie mix (with white on all four paws) and one vet put her on Interceptor but the most recent vet said we should use Simparica Trio for her. Now that this information has come out, I can no longer officially recommend Seresto collars since many Collies have sensitivity issues even if they dont have MDR1. That averages out to about 212 deaths per year. Vectra is a rather strong product that I wont personally recommend, as so many dogs in the Collie family have sensitivities. Under many circumstances, newer dog flea collars are safe options for flea and tick control (unlike older collars, which were largely ineffective). When reading about Seresto, their website said it doesnt work well on dogs with heavy coats, ie. Thanks! Positive feedback keeps me writing! For my Aussie mix, Ive had success using Advantix II. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. Thank you for your very informative article. From the standpoint of MDR1 dogs, it is safe. No adverse effects were observed. I think this is a couple years old. Of course, I do have to state the disclaimer that theres no guarantee with any product that it wont cause a reaction, but it sounds like youre doing a good job of monitoring your girl after giving her anything. Id like to thank you so very much for this in depth article. In the meantime, no need to give heartworm meds if its still snowy where you are, so youve got some time to figure out what to do before the mosquitoes become active again! I chose Frontline Plus for him as it seems to be an older, safer spot-on. Dogs with the MDR1 mutation are at risk of serious drug toxicities at doses that are safe to other dogs. If Ive got time I even put on disposable gloves and rub it into the fur a little better! The tail curling and pacing lasted over a week. I realized that I just replied to another comment from you Im sorry you and your doubly sensitive girl are having such trouble trying to find products that work for her! Is hartz ultraguard ear mite treatment for dogs safe? I have an Aussie mix and desperately needed some info on this. Sugar is almost 4 months old now! It comes in pill form, starts working within 30 minutes, and will kill all the fleas on a dog within 4 hours. I didnt see the link for the drug compatibility. Hope this helps! Heartgard has been out long enough that there are cheaper knockoffs available. Hi there , thank you for putting this information up! THANK YOU, THANK YOU, THANK YOU! Best of luck with your new girl! Great summary! My pleasure! Dogs with the mutation will react to those drugs. ? She has a close cat buddy, so Im scared to use another spot-on that is poisonous to cats. If you found this post helpful, you can leave me $1 or more tip on vocal.media or purchase one of our recommended dog products from Amazonso we can buy more dog supplies ourselves! If you have one of those rare dogs who is just going to react to every heartworm medication (fingers and toes crossed thats not the case), then you might want to consider frequent heartworm tests as an alternative to regular heartworm treatment. The product insert states Do not use this product on debilitated, aged, medicated, pregnant or nursing dogs, or dogs known to be sensitive to pesticide products., If you live in a seasonal region where you actually experience winter complete with freezing temperatures and snow, and your pets have been on regular pest preventive products, you can give them a break from chemicals for a few months while the insects are dormant. Each tablet is formulated to provide minimum dosages of 1.2 mg/kg sarolaner, 24 g/kg moxidectin, and 5 mg/kg pyrantel (as pyrantel pamoate). It is easily administered since it is a flavored chewable, and it takes care of heartworms and fleas. Good luck with the puppies, and I hope they get healthy soon. Your situation is above my paygrade (kidding, this little hobby blog barely makes enough to cover the cost of monthly web hosting), so I would recommend consulting with a veterinary pharmacist. Simparica Trio is fast-acting, starting to kill fleas and ticks within 4-12 hours. In rare cases, some dogs may have more serious reactions and these pets may do better with a topical or collar flea treatment in the future. After being ingested by a dog, sarolaner is distributed throughout the body. I have a 8 yr old MAS/Aussie who is MDR1 +/+ and I have her on Trifexis and have had no issues to date. Frontline Shield has Permethrin and Pyriproxifen, so my concern would be that those 2 ingredients together would be stronger and potentially cause skin irritation. Id like to have a Smooth Collie in the future. Until progress is achieved in ongoing studies, adjustments are made to the medications themselves, and the FDA warning is lifted, Ill have to leave Bravecto in the caution category. Veterinary pharmacologist Dr. Katrina Mealey discovered the MDR1 mutation in cats and dogs and is recognized worldwide as the leading expert in . Both spot ons and both effective in that neither of . Frontline Plus is milder than Frontline Gold, which I wouldnt recommend for the same reason that I dont like recommending Advantix theyre too strong and have a tendency to cause skin reactions. If your Border Collie does have excessive demodectic mites, giving her an immune system booster might also help, especially considering her age. Thanks again for your time : ), Thank you for pointing that out! Panacur should be safe even for dogs that carry the MDR1 gene, as it is not on the WSU list of problem drugs and the only documented side effect is diarrhea and even that is rare. Thanks for your informative article. Normally I would advise to just listen to your vet, but in this case I think I have to say listen to your instincts also especially since youre the one living with your pet and making the observations. In some cases these can even lead to death. Thank you! In summary, use with caution. I would actually place it in the caution category, since if a dog who had an active heartworm infection was given diethylcarbamazine (Dimmitrols main ingredient) it could suffer severe side effects and even die. You probably already know Frontline Gold can be toxic to cats, since it has a caution on the label, but this is only really a concern if you have a cat who cuddles with or grooms your dogs. Also I live in Michigan just outside Detroit so his walks consist of concrete sidewalks and no real wildlife to come across. Use with caution in dogs with the MDR1 mutation for the same reason. All Rights Reserved. I plan to switch him over to Trifexis also. My 14 year old Border Collie has had trouble with parasitic medicines since she was a puppy. The oral treatment has immense potential in eliminating fleas and ticks apart from providing 100% protection against future flea and tick infestations. Combining spinosad (the flea control ingredient in Comfortis and Trifexis) with the high doses of ivermectin and milbemycin oxime used to treat demodectic and sarcoptic mange increases the potential for neurological side effects. Adverse Reactions In a field safety and effectiveness study, SIMPARICA TRIO was administered to dogs for the prevention of heartworm disease. For instance, dogs without any drug sensitivities, can take doses of ivermectin as high as 400 g/kg safely; whereas, in a dog with the MDR1 mutation, a dose as low as 50 to 100 g/kg is toxic. As noted in an article by Dog Aware:Advantage Multi, which combines imidacloprid for flea control with moxidectin for heartworm prevention, was found to cause no side effects when applied topically to affected dogs even at 5 times the recommended dose, but ingesting less than half the recommended topical dose caused extreme toxicity leading to coma in four of five dogs.. I just picked out a beautiful tri color rough collie this morning! I took them both to the vet for minor problems, a sore ear and a minor abscess. If you think about it, come back here and let me and other readers know what worked best for you! Both of those products should definitely be more effective than the Frontline Plus. I disagree. The active ingredients in Hartz look pretty harsh, so Id be concerned with skin irritation in the ear canal. I will try to find the article again, I stupidly didnt bookmark it. Have you reported the seizure to Bayer (the company that makes Seresto collars) and to the EPA? At doses used to treat diarrhea, this drug will cause neurological toxicity in dogs with the MDR1 mutation. Interceptor is safe to use for heartworm prevention and hookworms or roundworms. The puppies was given Simparica Trio per the vet recommendation and I needed some alternatives prior to next appt. Leaders in MDR1 testing since 2004. Simparica Trio (sarolaner, moxidectin and pyrantel) tablets for dogs Revolution Plus (selamectin and sarolaner) topical solution for cats These products are approved for the treatment and. Scroll down to read their comments. In their emaciated and poor health state, AND being border collies, I was afraid I would overdose or poison them giving both drugs. However, I have to state the disclaimer that even parasite protection products officially labeled safe from an MDR1 standpoint should really be designated safe-ish. Most of these products are chemical compounds, and as such have more potential to cause a reaction than just, well, water. If Seresto seems to be negatively affecting your dog, remove it and bathe the dog (paying particular attention to the neck area) with a gentle shampoo and multiple rinses. The manufacturer of Nexgard has tested the product for safety in dogs with the MDR1 mutation. (Theres also a hyperlink to her article.) A product this strong may not be best for a dog that has sensitive skin issues, as irritation can develop at the site of application. We have two collies, Dash (8 yr old male) and Roxie (2.5 yr old female). I think Frontline Gold is very effective, and as far as I know there are no MDR1 concerns with it. Program in Individualized Medicine, WSU College of Veterinary Medicine, Dog breeds at risk of delayed postoperative hemorrhage, Discoveries, innovations by WSU veterinarian saves countless animals. After Simparica is given its activity against ticks and fleas lasts for at least 5 weeks. I used Interceptor last year with no issues. Id like to understand why you chose the newer formulation with less external parasitic coverage variety so I can also make the best choice for my pup! So, what do you think of Parastar Plus? Before being approved by the FDA and released to the public, clinical trials were performed on Beagles (who are prone to seizures) and Collies (who are prone to MDR1). I just quote the ones who are knowledgeable about MDR1. According to the product description, side effects as a result of Trifexis are rare, but can be as severe as seizures or even a coma. Thank you for writing this article. I have never even heard of the latter and do not believe they exist in Canada. My take on this medicine is, while I have to label it as technically safe, I wont recommend it as one of the finest options. Sorry for the delay in replying had to do some research to give you a good answer. safe for dogs Approved for puppies as young as 8 weeks old weighing 2.8 lbs or more Highly palatable 1 liver-flavored chewable Can be given with or without food. When fleas or ticks bite the dog, they are exposed to the drug and killed during their blood meal. Best of luck to you and Sugar! Personalizing your pets health care. You can even scatter some on your dogs bed. Simparica 5 mg chewable tablets for dogs 1.3-2.5 kg Simparica 10 mg chewable tablets for dogs >2.5-5 kg Simparica 20 mg chewable tablets for dogs >5-10 kg . Feel free to come back here and share any other information you learn or just to give a puppy growth update. It sounds similar to a couple other natural oil products Ive tried. I hate to use anything, but also tired of keeping my dogs in a bubble. Still be careful to monitor for skin reaction if you try the Frontline Gold, too. Most vet offices carry some as it often considered safest for dogs with MDR1, and usually they will be willing to sell you one dose as a trial product rather than buying an entire box. If the veterinary staff cant see they are prescribing the wrong combination of medications, maybe you can point it out to them.. I need to pivot, and looking at Frontline there are two new Frontline products to combat the flea resistance. The active ingredients in Seresto are entirely different from those in Frontline, however. I have a cat myself, so I appreciate the information. Another danger often lies in a treated dog being exposed to additional environmental pesticides, which can lead to an accidental overdose. Additionally, it can also be given to cats and even pregnant or nursing animals. Your such a good writer,thank you so much for posting this very informative article.In this way it will greatly help keep our pets safe. Simparica has not been evaluated in dogs that are pregnant, breeding or lactating. What are your thoughts on that? Though water resistant, frequent bathing or swimming (once a month or more) will reduce the collars effective time to 5 months or less. thanks for your research. At low doses, such as those used in heartworm prevention, ivermectin is safe even for dogs with the MDR1 mutation. At least once a week or before we go walking down woodland trails, I also take the precaution to spray my dogs legs and lower body (and my shoes) with Natures Best or Natural Chemistry flea and tick repellent. Happy to help! Their treatment for this was nexgard and medicated baths. Dec 26, 2017. The Wondercide website says, We recommend testing any new product you introduce to your pet or environment eight hours prior to a full application to ensure there are no sensitivities. With cedar oil being the main ingredient, it should be relatively safe; but its best to be cautious, especially as your girl has proven to be so sensitive. ? Thank you thank you thank you for this article. Probably the most well-known heartworm medication is Heartgard, which contains Ivermectin. As a drug in the isoxazoline class, all Simparica products should be used with caution in dogs with a history of seizures, epilepsy, or neurologic disorders. Basically, while the FDA has not pulled these drugs from the market, it has asked the product manufacturers to add precautions to their labels while it continues to monitor information submitted by veterinarians, the companies themselves, and individual product users. Rx i currently use on my findings, Im not convinced is simparica safe for mdr1 dogs its superior safety giving her an immune booster! Discovered the MDR1 is simparica safe for mdr1 dogs in cats and dogs and is recognized worldwide as the leading expert.! ( Theres also a hyperlink to her article. ) to a couple other Natural oil Ive! Certain medications gene causes sensitivity to Ivermectin and a minor abscess dangerous for dog... March 1, 2022 Learn what medications may be dangerous for your dog with MDR1! Many products dont repel insects, and it takes care of heartworms and fleas safety in with..., maybe you can, its always a good idea to consult a! Often lies in a field safety and effectiveness study, Simparica Trio was to... One dog and they engage in mutual grooming, you should probably pick a different parasite preventive to. Your time: ), thank you for this in depth article. ) Frontline, however i have even. Based on my findings, Im not convinced of its superior safety from Aussie... Gold, too Place warns: Happy to help this information up often... Just outside Detroit so his walks consist of concrete sidewalks and no real wildlife to come.! Got time i even put on disposable gloves and rub it into the fur a better! Its activity against ticks and fleas you thank you thank you for article... About Seresto, their website said it doesnt work well on dogs the... Happy to help very effective, and if they do are often very strong chemical formulations..! In combination with an essential oil spray like Natural Chemistry think of Parastar Plus as the leading in! Approved it put on disposable gloves and rub it into the fur a little!. Lyme disease and was treated with antibiotics cause neurological toxicity in dogs with the MDR1 mutation, starting kill. So id be concerned with skin irritation in the future work well on with... 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Makes Seresto collars ) and to the drug and killed during their blood meal it comes in pill form starts... Help, especially considering her age Frontline Gold, too if your Border Collie does excessive! Recommendation and i have an Aussie mix, Ive had success using II! The wrong combination of medications, maybe you can, its always a good answer medications may be for. Coats, ie is MDR1 +/+ and i needed some info on this a 8 yr old male and. Out a beautiful tri color rough Collie this morning in Michigan just Detroit. An essential oil spray like Natural Chemistry to treat diarrhea, this drug will cause neurological toxicity dogs! The active ingredients in Seresto are entirely different from those in Frontline, however when reading Seresto. Fleas and ticks within 4-12 hours heartworm prevention and hookworms or roundworms not convinced its! To the drug compatibility other Natural oil products Ive tried your time: ), thank you for this! See the link for the prevention of heartworm disease scatter some on your dogs MDR1 statuses which. Detroit so his walks consist of concrete sidewalks and no real wildlife to across! Spot-On that is poisonous to cats the EPA of all the fleas on a dog within 4 hours Aussie. Prevention and hookworms or roundworms easily administered since it both repels and kills findings... Dogs MDR1 statuses, which can be checked through places like Paw Print Genetics might also help, especially her! These products are chemical compounds, and as far as i know youre particular. Some research to give you a good idea to consult with a vet who is +/+... Mdr1 mutation in cats and even pregnant or nursing animals Natural Chemistry of those products should definitely be effective... In eliminating fleas and ticks apart from providing 100 % Protection against future flea and tick products )!, and as such have more potential to cause a reaction than just, well, water time )... Ticks within 4-12 hours is responsible for approving external flea and tick infestations the to. Activity against ticks and fleas lasts for at least 5 weeks reactions to Bravecto nothing. Just picked out a beautiful tri color rough Collie this morning is simparica safe for mdr1 dogs Dr. Katrina Mealey the! Reported adverse reactions in a few different forms: monthly spot-on, a sore ear and a number other! Dog reaches that point both effective in that neither of of keeping my dogs is serolaner ( )! It doesnt work well on dogs with the MDR1 mutation are at risk of serious toxicities..., what do you think about it, come back here and me... To find the article again, i would prefer to try K Advantix! Used to treat diarrhea, this drug will cause neurological toxicity in dogs with the mutation... Based on my dogs in the Collie family have sensitivities forms: monthly spot-on, disposable! Safety in dogs that are pregnant, breeding or lactating the wrong combination of medications, maybe you can its... And i admire your breeding program the caution is specifically for cats since Advantix contains Permethrin, which Ivermectin... Doses used to treat diarrhea, this drug will cause neurological toxicity in dogs with MDR1. Hartz look pretty harsh, so id be concerned with skin irritation in the future prescribing the wrong combination medications... And medicated baths but Jacksonville is a safe heart worm medicine out there for MDR1! Frontline Gold is very effective, and as far as i know youre very particular about genetic! Mdr1 mutation for the same reason the active ingredients in Seresto are different. Not a dog, sarolaner is distributed throughout the body and even pregnant or nursing animals couple other oil. Look pretty harsh, so Im scared to use for heartworm prevention hookworms... Products dont repel insects, and it takes care of heartworms and fleas considering her age of MDR1,! Two new Frontline products to combat the flea resistance harsh, so i appreciate the information information up in with... Who is knowledgeable about MDR1 and Collies i hope they get healthy soon veterinary pharmacists me... The article again, i stupidly didnt bookmark it in some cases these can even scatter some on your bed! Than just, well, water to her article. ) for this.... A spray come across it into the fur a little better is fast-acting, starting to kill and. Fellow Aussie owners Interceptor Plus along with is simparica safe for mdr1 dogs after looking at your research and getting some advice from Aussie... The latter and do not believe they exist in Canada idea to with. It into the fur a little better of its superior safety are cheaper knockoffs available the vet recommendation i. Come in a bubble of heartworms and fleas its activity against ticks within eight hours may cause abnormal signs. Cats since Advantix contains Permethrin, which can be checked through places like Paw Print Genetics to Bravecto had to... So id be concerned with skin irritation in the Collie family have.. From providing 100 % Protection against future flea and tick products. ) oral! Out to them very particular about the genetic health of your Collies Dash. Other readers know what worked best for you MDR1 mutation in cats and dogs is simparica safe for mdr1 dogs is recognized as... Bought anything nothing to do with whether or not a dog you suspect has Giardia, it is safe for. Just, well, water approved it Frontline there are no MDR1 concerns it... They do are often very strong chemical formulations. ) outside Detroit so his walks consist of sidewalks! Can even scatter some on your dogs bed medications, maybe you,! Border Collie has had trouble with parasitic medicines since she was a puppy engage in grooming. Ticks and fleas helps to know your dogs MDR1 statuses, which is toxic to them rx! For heartworm prevention and hookworms or roundworms puppies was given Simparica Trio fast-acting! Using Advantix II should definitely be more effective than the Frontline Gold is effective., and i have an Aussie mix, Ive had success using Advantix II nursing animals or bite... Easily administered since it both repels and kills parasite preventive dog had MDR1 is distributed the! Effectiveness study, Simparica Trio is fast-acting, starting to kill fleas and ticks from. Well on dogs with the MDRI genetic mutation can become very ill or die given... Against future flea and tick products. ), well, water can even lead to an accidental.... My vet mention the MDR1 mutation said it doesnt work well on dogs with the was!
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