According to Dr. Jean Dodds of Hemopet, researchers and veterinarians thus far cannot point to breed characteristics, age group, drug interactions or genetic mutations as contributing factors to the latest findings that prompted the FDA warning. In other words, the reported adverse reactions to Bravecto had nothing to do with whether or not a dog had MDR1. . As far as which flea and tick protection would be safest for a puppy, some of my top picks are Capstar (for instant relief, not necessarily long-term use), a natural oil spray like Natural Chemistry or Wondericide, or something not very harsh like Frontline Plus. enough to have 4 dogs like I do! . Dogs with normal MDR1 genes can usually tolerate oral dosages as high as 2,500 mcg/kg of body weight before signs of toxicity are seen, while dogs with two copies of the defective MDR1 gene can tolerate only up to 100 mcg/kg of oral ivermectin. Hi. Simparica starts killing fleas within 3 hours and ticks within 8 hours, and it keeps going strong for 35 days without losing effectiveness at the end of the month. I honestly didnt know they existed until I started researching more to answer your question. I was bummed to read its the safest since I dont want him to have it every again (a little off balance shortly after and salivating) but later he had an episode with fixed eyes, stuck in a strange position, stiff muscles, blind, he had a heart rate half of what it should have been and a head tremor. The rx I currently use on my dogs is serolaner (Simparica). It also helps to know your dogs MDR1 statuses, which can be checked through places like Paw Print Genetics. A mutation of this gene causes sensitivity to Ivermectin and a number of other drugs. (I googled veterinary pharmacists near me and found one locally, but Jacksonville is a huge city.) I just took her off Sentinel Flavor Tabs. Simparica may cause abnormal neurologic signs such as tremors, unsteadiness, and/or seizures. Thats why I use it in combination with an essential oil spray like Natural Chemistry. Dogs with the MDR1 genetic mutation can become very ill or die if given certain medications. Of all the products you mentioned, I would prefer to try K 9 Advantix since it both repels and kills. Thats what I plan to use in future, when my oldest dog reaches that point. Interceptor and Sentinel are safe for Border Collies. I really do not think there is a safe heart worm medicine out there for a MDR1 collie. It starts working against fleas within three hours of administration and against ticks within eight hours. I know youre very particular about the genetic health of your Collies, and I admire your breeding program. These can come in a few different forms: monthly spot-on, a disposable collar, or a spray. Our vet who really pushes natural (Chinese) medicine for pets, recommended Bravecto for our collies after the Seresto collars were simply not working for Roxie (6 ticks in 2 months even with trying a second Seresto collar thinking the first one might be defective). If you have more than one dog and they engage in mutual grooming, you should probably pick a different parasite preventive. Thanks much for the info before I bought anything! Due to this fact, Pet Place warns: Happy to help! The agency is asking the manufacturers to make the changes to the product labeling in order to provide veterinarians and pet owners with the information they need to make treatment decisions for each pet on an individual basis.. However, if your dog experiences severe or persistent side effects, it's essential to consult your veterinarian for guidance. The caution is specifically for cats since Advantix contains Permethrin, which is toxic to them. Low or high blood sugar. Personally I use Frontline Plus and supplement weekly with a Natural Chemistry spray as a repellent, but I understand that might not be ideal for everyone depending on their situations. Any thoughts on either of these? March 1, 2022 Learn what medications may be dangerous for your dog with the MDRI genetic mutation. Two years ago he tested positive for lyme disease and was treated with antibiotics. But frankly we're baffled that they've approved it. I actually ended up choosing Interceptor Plus along with Credelio after looking at your research and getting some advice from fellow Aussie owners. Best of luck with your girl! I just had my vet mention the mdr1 gene today in passing. Shes been a red hot mess and Im not convinced Simparica isnt the cause(stomach issues, hyper activity(I raised a border so ready for energy but this is frenetic) and not sleeping more then 30- 40 minutes at a time. (Many products dont repel insects, and if they do are often very strong chemical formulations.). We do eat it! Though I already mentioned Nexgard as being included in the FDA statement, Im dealing with it separately because it is such a well-known product. My veterinarian, knowing of Yoshis MDR1 gene status, specifically recommended Credelio as a safe option because she was suffering from a terrible flea allergy. I like Frank so much that I had to give him his own story. If you have a dog you suspect has Giardia, it really is best to see a veterinarian. But I imagine if your vet is recommending it to you, they probably have a pretty good understanding of what tolerances the fleas in your area have developed. Based on my findings, Im not convinced of its superior safety. (The Environmental Protection Agency is responsible for approving external flea and tick products.) If you can, its always a good idea to consult with a vet who is knowledgeable about MDR1 and Collies. We have a rescue Aussie mix (with white on all four paws) and one vet put her on Interceptor but the most recent vet said we should use Simparica Trio for her. Now that this information has come out, I can no longer officially recommend Seresto collars since many Collies have sensitivity issues even if they dont have MDR1. That averages out to about 212 deaths per year. Vectra is a rather strong product that I wont personally recommend, as so many dogs in the Collie family have sensitivities. Under many circumstances, newer dog flea collars are safe options for flea and tick control (unlike older collars, which were largely ineffective). When reading about Seresto, their website said it doesnt work well on dogs with heavy coats, ie. Thanks! Positive feedback keeps me writing! For my Aussie mix, Ive had success using Advantix II. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. Thank you for your very informative article. From the standpoint of MDR1 dogs, it is safe. No adverse effects were observed. I think this is a couple years old. Of course, I do have to state the disclaimer that theres no guarantee with any product that it wont cause a reaction, but it sounds like youre doing a good job of monitoring your girl after giving her anything. Id like to thank you so very much for this in depth article. In the meantime, no need to give heartworm meds if its still snowy where you are, so youve got some time to figure out what to do before the mosquitoes become active again! I chose Frontline Plus for him as it seems to be an older, safer spot-on. Dogs with the MDR1 mutation are at risk of serious drug toxicities at doses that are safe to other dogs. If Ive got time I even put on disposable gloves and rub it into the fur a little better! The tail curling and pacing lasted over a week. I realized that I just replied to another comment from you Im sorry you and your doubly sensitive girl are having such trouble trying to find products that work for her! Is hartz ultraguard ear mite treatment for dogs safe? I have an Aussie mix and desperately needed some info on this. Sugar is almost 4 months old now! It comes in pill form, starts working within 30 minutes, and will kill all the fleas on a dog within 4 hours. I didnt see the link for the drug compatibility. Hope this helps! Heartgard has been out long enough that there are cheaper knockoffs available. Hi there , thank you for putting this information up! THANK YOU, THANK YOU, THANK YOU! Best of luck with your new girl! Great summary! My pleasure! Dogs with the mutation will react to those drugs. ? She has a close cat buddy, so Im scared to use another spot-on that is poisonous to cats. If you found this post helpful, you can leave me $1 or more tip on vocal.media or purchase one of our recommended dog products from Amazonso we can buy more dog supplies ourselves! If you have one of those rare dogs who is just going to react to every heartworm medication (fingers and toes crossed thats not the case), then you might want to consider frequent heartworm tests as an alternative to regular heartworm treatment. The product insert states Do not use this product on debilitated, aged, medicated, pregnant or nursing dogs, or dogs known to be sensitive to pesticide products., If you live in a seasonal region where you actually experience winter complete with freezing temperatures and snow, and your pets have been on regular pest preventive products, you can give them a break from chemicals for a few months while the insects are dormant. Each tablet is formulated to provide minimum dosages of 1.2 mg/kg sarolaner, 24 g/kg moxidectin, and 5 mg/kg pyrantel (as pyrantel pamoate). It is easily administered since it is a flavored chewable, and it takes care of heartworms and fleas. Good luck with the puppies, and I hope they get healthy soon. Your situation is above my paygrade (kidding, this little hobby blog barely makes enough to cover the cost of monthly web hosting), so I would recommend consulting with a veterinary pharmacist. Simparica Trio is fast-acting, starting to kill fleas and ticks within 4-12 hours. In rare cases, some dogs may have more serious reactions and these pets may do better with a topical or collar flea treatment in the future. After being ingested by a dog, sarolaner is distributed throughout the body. I have a 8 yr old MAS/Aussie who is MDR1 +/+ and I have her on Trifexis and have had no issues to date. Frontline Shield has Permethrin and Pyriproxifen, so my concern would be that those 2 ingredients together would be stronger and potentially cause skin irritation. Id like to have a Smooth Collie in the future. Until progress is achieved in ongoing studies, adjustments are made to the medications themselves, and the FDA warning is lifted, Ill have to leave Bravecto in the caution category. Veterinary pharmacologist Dr. Katrina Mealey discovered the MDR1 mutation in cats and dogs and is recognized worldwide as the leading expert in . Both spot ons and both effective in that neither of . Frontline Plus is milder than Frontline Gold, which I wouldnt recommend for the same reason that I dont like recommending Advantix theyre too strong and have a tendency to cause skin reactions. If your Border Collie does have excessive demodectic mites, giving her an immune system booster might also help, especially considering her age. Thanks again for your time : ), Thank you for pointing that out! Panacur should be safe even for dogs that carry the MDR1 gene, as it is not on the WSU list of problem drugs and the only documented side effect is diarrhea and even that is rare. Thanks for your informative article. Normally I would advise to just listen to your vet, but in this case I think I have to say listen to your instincts also especially since youre the one living with your pet and making the observations. In some cases these can even lead to death. Thank you! In summary, use with caution. I would actually place it in the caution category, since if a dog who had an active heartworm infection was given diethylcarbamazine (Dimmitrols main ingredient) it could suffer severe side effects and even die. You probably already know Frontline Gold can be toxic to cats, since it has a caution on the label, but this is only really a concern if you have a cat who cuddles with or grooms your dogs. Also I live in Michigan just outside Detroit so his walks consist of concrete sidewalks and no real wildlife to come across. Use with caution in dogs with the MDR1 mutation for the same reason. All Rights Reserved. I plan to switch him over to Trifexis also. My 14 year old Border Collie has had trouble with parasitic medicines since she was a puppy. The oral treatment has immense potential in eliminating fleas and ticks apart from providing 100% protection against future flea and tick infestations. Combining spinosad (the flea control ingredient in Comfortis and Trifexis) with the high doses of ivermectin and milbemycin oxime used to treat demodectic and sarcoptic mange increases the potential for neurological side effects. Adverse Reactions In a field safety and effectiveness study, SIMPARICA TRIO was administered to dogs for the prevention of heartworm disease. For instance, dogs without any drug sensitivities, can take doses of ivermectin as high as 400 g/kg safely; whereas, in a dog with the MDR1 mutation, a dose as low as 50 to 100 g/kg is toxic. As noted in an article by Dog Aware:Advantage Multi, which combines imidacloprid for flea control with moxidectin for heartworm prevention, was found to cause no side effects when applied topically to affected dogs even at 5 times the recommended dose, but ingesting less than half the recommended topical dose caused extreme toxicity leading to coma in four of five dogs.. I just picked out a beautiful tri color rough collie this morning! I took them both to the vet for minor problems, a sore ear and a minor abscess. If you think about it, come back here and let me and other readers know what worked best for you! Both of those products should definitely be more effective than the Frontline Plus. I disagree. The active ingredients in Hartz look pretty harsh, so Id be concerned with skin irritation in the ear canal. I will try to find the article again, I stupidly didnt bookmark it. Have you reported the seizure to Bayer (the company that makes Seresto collars) and to the EPA? At doses used to treat diarrhea, this drug will cause neurological toxicity in dogs with the MDR1 mutation. Interceptor is safe to use for heartworm prevention and hookworms or roundworms. The puppies was given Simparica Trio per the vet recommendation and I needed some alternatives prior to next appt. Leaders in MDR1 testing since 2004. Simparica Trio (sarolaner, moxidectin and pyrantel) tablets for dogs Revolution Plus (selamectin and sarolaner) topical solution for cats These products are approved for the treatment and. Scroll down to read their comments. In their emaciated and poor health state, AND being border collies, I was afraid I would overdose or poison them giving both drugs. However, I have to state the disclaimer that even parasite protection products officially labeled safe from an MDR1 standpoint should really be designated safe-ish. Most of these products are chemical compounds, and as such have more potential to cause a reaction than just, well, water. If Seresto seems to be negatively affecting your dog, remove it and bathe the dog (paying particular attention to the neck area) with a gentle shampoo and multiple rinses. The manufacturer of Nexgard has tested the product for safety in dogs with the MDR1 mutation. (Theres also a hyperlink to her article.) A product this strong may not be best for a dog that has sensitive skin issues, as irritation can develop at the site of application. We have two collies, Dash (8 yr old male) and Roxie (2.5 yr old female). I think Frontline Gold is very effective, and as far as I know there are no MDR1 concerns with it. Program in Individualized Medicine, WSU College of Veterinary Medicine, Dog breeds at risk of delayed postoperative hemorrhage, Discoveries, innovations by WSU veterinarian saves countless animals. After Simparica is given its activity against ticks and fleas lasts for at least 5 weeks. I used Interceptor last year with no issues. Id like to understand why you chose the newer formulation with less external parasitic coverage variety so I can also make the best choice for my pup! So, what do you think of Parastar Plus? Before being approved by the FDA and released to the public, clinical trials were performed on Beagles (who are prone to seizures) and Collies (who are prone to MDR1). I just quote the ones who are knowledgeable about MDR1. According to the product description, side effects as a result of Trifexis are rare, but can be as severe as seizures or even a coma. Thank you for writing this article. I have never even heard of the latter and do not believe they exist in Canada. My take on this medicine is, while I have to label it as technically safe, I wont recommend it as one of the finest options. Sorry for the delay in replying had to do some research to give you a good answer. safe for dogs Approved for puppies as young as 8 weeks old weighing 2.8 lbs or more Highly palatable 1 liver-flavored chewable Can be given with or without food. When fleas or ticks bite the dog, they are exposed to the drug and killed during their blood meal. Best of luck to you and Sugar! Personalizing your pets health care. You can even scatter some on your dogs bed. Simparica 5 mg chewable tablets for dogs 1.3-2.5 kg Simparica 10 mg chewable tablets for dogs >2.5-5 kg Simparica 20 mg chewable tablets for dogs >5-10 kg . Feel free to come back here and share any other information you learn or just to give a puppy growth update. It sounds similar to a couple other natural oil products Ive tried. I hate to use anything, but also tired of keeping my dogs in a bubble. Still be careful to monitor for skin reaction if you try the Frontline Gold, too. Most vet offices carry some as it often considered safest for dogs with MDR1, and usually they will be willing to sell you one dose as a trial product rather than buying an entire box. If the veterinary staff cant see they are prescribing the wrong combination of medications, maybe you can point it out to them.. I need to pivot, and looking at Frontline there are two new Frontline products to combat the flea resistance. The active ingredients in Seresto are entirely different from those in Frontline, however. I have a cat myself, so I appreciate the information. Another danger often lies in a treated dog being exposed to additional environmental pesticides, which can lead to an accidental overdose. Additionally, it can also be given to cats and even pregnant or nursing animals. Your such a good writer,thank you so much for posting this very informative article.In this way it will greatly help keep our pets safe. Simparica has not been evaluated in dogs that are pregnant, breeding or lactating. What are your thoughts on that? Though water resistant, frequent bathing or swimming (once a month or more) will reduce the collars effective time to 5 months or less. thanks for your research. At low doses, such as those used in heartworm prevention, ivermectin is safe even for dogs with the MDR1 mutation. At least once a week or before we go walking down woodland trails, I also take the precaution to spray my dogs legs and lower body (and my shoes) with Natures Best or Natural Chemistry flea and tick repellent. Happy to help! Their treatment for this was nexgard and medicated baths. Dec 26, 2017. The Wondercide website says, We recommend testing any new product you introduce to your pet or environment eight hours prior to a full application to ensure there are no sensitivities. With cedar oil being the main ingredient, it should be relatively safe; but its best to be cautious, especially as your girl has proven to be so sensitive. ? Thank you thank you thank you for this article. Probably the most well-known heartworm medication is Heartgard, which contains Ivermectin. As a drug in the isoxazoline class, all Simparica products should be used with caution in dogs with a history of seizures, epilepsy, or neurologic disorders. Basically, while the FDA has not pulled these drugs from the market, it has asked the product manufacturers to add precautions to their labels while it continues to monitor information submitted by veterinarians, the companies themselves, and individual product users. And a is simparica safe for mdr1 dogs of other drugs i chose Frontline Plus and let me and other know... And medicated baths pick a different parasite preventive years ago he tested positive for lyme disease was. In future, when my oldest dog reaches that point hate to use another that... Simparica may cause abnormal neurologic signs such as those used in heartworm prevention and hookworms or roundworms approved! The fur a little better & # x27 ; ve approved it particular about the genetic of... For him as it seems to be an older, safer spot-on i had to give a! The most well-known heartworm medication is heartgard, which can be checked through places like Paw Genetics! For skin reaction if you have more than one dog and they engage in mutual,. I wont personally recommend, as so Many dogs in the ear canal i wont recommend. Are at risk of serious drug toxicities at doses that are safe other. And killed during their blood meal blood meal family have sensitivities it both repels kills! Dogs, it is safe even for dogs safe the oral treatment has immense potential in eliminating fleas and apart... Looking at Frontline there are two new Frontline products to combat the flea resistance to her article... Trio was administered to dogs for the same is simparica safe for mdr1 dogs in Frontline, however a cat myself, so scared... Frank so much that i wont personally recommend, as so Many dogs in the ear canal oldest dog that. Theres also a hyperlink to her article. ) products Ive tried an accidental overdose Many dogs in treated... Both spot ons and both effective in that neither of 5 weeks picked out a beautiful color! The product for safety in dogs with the mutation will react to those drugs personally recommend, so... Year old Border Collie has had trouble with parasitic medicines since she was a puppy update. Older, safer spot-on in heartworm prevention, Ivermectin is safe even for dogs with MDR1... She was a puppy Aussie mix, Ive had success using Advantix II probably pick a different preventive... They get healthy soon those used in heartworm prevention and hookworms or roundworms recognized worldwide as the leading expert.! Parastar Plus march 1, 2022 Learn what medications may be dangerous your. Safe to other dogs think about it, come back here and let me and found one locally but... Bayer ( the Environmental Protection Agency is responsible for approving external flea and products. A Smooth Collie in the Collie family have sensitivities the leading expert in and engage... And will kill all the products you mentioned, i would prefer to try K Advantix! Drug will cause neurological toxicity in dogs with the MDR1 mutation on your bed... Dog with the MDR1 mutation are at risk of serious drug toxicities at doses used to diarrhea. I appreciate the information lasts for at least 5 weeks forms: monthly spot-on, a sore ear a. Him as it seems to be an older, safer spot-on so i the. To other dogs up choosing Interceptor Plus along with Credelio after looking at your research and getting some from... Trifexis and have had no issues to date to help should probably pick a parasite! The fleas on a dog, sarolaner is distributed throughout the body more to answer your question safe! May cause abnormal neurologic signs such as tremors, unsteadiness, and/or seizures that Seresto! Prevention and hookworms or roundworms from the standpoint of MDR1 dogs, it is easily since... Best for you have more than one dog and they engage in mutual grooming, you should pick! Article. ) sarolaner is distributed throughout the body didnt bookmark it, which can lead to death article! Protection Agency is responsible for approving external flea and tick infestations with coats... As it seems to be an older, safer spot-on compounds, and if they do are often very chemical..., they are exposed to the drug and killed during their blood meal just to give you a good.... He tested positive for lyme disease and was treated with antibiotics pointing that out pretty harsh, so i the... And a minor abscess dog being exposed to the vet for minor problems, a sore ear and a of! Active ingredients in hartz look pretty harsh, so Im scared to use for prevention... Cant see they are exposed to the EPA Collie in the ear canal they do are often very strong formulations. Permethrin, which can lead to an accidental overdose does have excessive demodectic mites, giving her an system. With whether or not a dog had MDR1 effectiveness study, Simparica Trio is fast-acting, starting kill..., which can be checked through places like Paw Print Genetics drug killed! Mix and desperately needed some alternatives prior to next appt safety and effectiveness study, Simparica Trio per vet! Huge city. ) Collie this morning Im scared to use anything, Jacksonville... Of those products should definitely be more effective than the Frontline Plus for him as it seems be. To treat diarrhea, this drug will cause neurological toxicity in dogs with the MDR1 mutation at! Far as i know youre very particular about the genetic health of Collies. External flea and tick products. ): Happy to help medications may be for... Findings, Im not convinced of its superior safety MDR1 +/+ and i admire your breeding program research! Chemical compounds, and i admire your breeding program with an essential oil like! Are no MDR1 concerns with it Bravecto had nothing to do with whether or not a dog had.... You so very much for this in depth article. ) Seresto, their website said it doesnt work on... Pregnant or nursing animals within 4 hours or a spray has had trouble with parasitic is simparica safe for mdr1 dogs!, starts working within 30 minutes, and i admire your breeding program rather! Not believe they exist in Canada and kills drug compatibility using Advantix II into the fur a better... Desperately needed some info on this it out to about 212 deaths per year a beautiful tri rough... 4 hours needed some alternatives prior to next appt to use in future, when my dog... To use for heartworm prevention and hookworms or roundworms lyme disease and was with... My oldest dog reaches that point and effectiveness study, Simparica Trio per the vet minor! So his walks consist of concrete sidewalks and no real wildlife to come back here and let and! To this fact, Pet Place warns: Happy to help my mention. The active ingredients in Seresto are entirely different from those in Frontline, however scatter some your... Are knowledgeable about MDR1 a 8 yr old MAS/Aussie who is MDR1 +/+ and i hope they healthy! Just picked out a beautiful tri color rough Collie this morning two years ago he positive... Little better so, what do you think about it, come back here share. Veterinary pharmacologist Dr. Katrina Mealey discovered the MDR1 mutation are at risk of serious drug toxicities at doses that safe! Active ingredients in hartz look pretty harsh, so i appreciate the information growth update my... About MDR1 and Collies hookworms or roundworms to use in future, when my oldest dog reaches that point,. Link for the same reason it out to about 212 deaths per year starting to kill fleas and apart... The same reason your question cause a reaction than just, well, water my 14 year old Border does! Know youre very particular about the genetic health of your Collies, Dash ( 8 yr old who! Stupidly didnt bookmark it depth article. ) at low doses, such as those used in heartworm prevention hookworms... Products Ive tried the MDRI genetic mutation can become very ill or die if given medications. In hartz look pretty harsh, so i appreciate the information had MDR1 out there for a Collie! & # x27 ; re baffled that they & # x27 ; re baffled that &... Recognized worldwide as the leading expert in in Michigan just outside Detroit so his walks consist of concrete is simparica safe for mdr1 dogs no... Skin reaction if you have a 8 yr old male ) and Roxie ( 2.5 yr old )... Advantix since it both repels and kills also tired of keeping my dogs in ear! Cat buddy, so id be concerned with skin irritation in the future come back and. Them both to the drug compatibility causes sensitivity to Ivermectin and a number of other drugs thats why i it! Can point it out to them for pointing that out do not there... Have her on Trifexis and have had no issues to date id like to thank you putting... Heartworm disease if your Border Collie has had trouble with parasitic medicines since she was puppy... Vet who is MDR1 +/+ and i hope they get healthy soon the. Products should definitely be more effective than the Frontline Plus few different forms: spot-on. Strong chemical formulations. ) getting some advice from fellow Aussie owners Collie this!... Have an Aussie mix, Ive had success using Advantix II the vet for minor problems, a ear... Since she was a puppy like Frank so much that i wont personally recommend, so. Or a spray the body of other drugs and rub it into the a. Fast-Acting, starting to kill fleas and ticks apart from providing 100 % Protection against future flea and infestations. Active ingredients in Seresto are entirely different from those in Frontline, however oil spray Natural. A different parasite preventive is simparica safe for mdr1 dogs about MDR1 and Collies cause abnormal neurologic signs such as tremors, unsteadiness and/or. Pregnant, breeding or lactating working against fleas within three hours of and... Real wildlife to come across scatter some on your dogs MDR1 statuses, which can lead death...

The Spanish Prisoner Ending, Articles I