Long-term use can result in muscular weakness, bone loss, potassium loss, and irregular heart rhythm. Right off the bat, the claims are rather challenging. Inhibition of cytochrome P450 enzymes by rhein in rat liver microsomes. Further a recent preclinical study excluded unwanted side effects on Diarrhea can increase the effects of warfarin and increase the risk of bleeding. Methods Find.Exp Clin Pharmacol 1993;15(1):23-29. Some medications can also harm the kidneys. Zhong.Xi.Yi.Jie.He.Za Zhi. It is POSSIBLY SAFE for most adults when taken by mouth in medicinal amounts for up to 3 months. View abstract. Jin, H. M. and Jiao, D. H. [Effect of jiang-zhi jian-fei yao on gastro-intestinal movement and adipose cell of abdominal wall]. Learn about the difference between menopause, premenopause, and perimenopause here. Li, L. S. and Liu, Z. H. [Clinical and experimental studies of rheum on preventing progression of chronic renal failure] (Chinese). Effects of rhubarb tannins on renal function in rats with renal failure. Another main ingredient of Estroven is soy isoflavones. 3 E Evergreen Road #1193, New City, NY 10956 View abstract. Z., Kang, B., and Zhu, Q. Q. View abstract. Pharmacology 1976;14:48-61. In vitro binding of bile salt to rhubarb stalk powder. Rhein has in vitro antimicrobial activity against a wide spectrum of gram-negative and gram-positive bacteria.13, 39, 41, An extract of rhubarb stalk has been used as a dental desensitizer. Their perimenopausal treatment aims to regulate the menstrual cycle. The side effects of Rhubarb are somehow dependent on how long a person has consumed it as a medicine. However, their Amazon customer rating is 4.3 out of 5 stars. Zhonghua Yi.Xue.Za Zhi. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. Always consult your doctor before using any supplements. However, a person should speak with a doctor before taking either product. Contains Clinically Proven, Plant-Based Rhaphontic Rhubarb Root Extract. Resume of 400 cases of acute upper digestive tract bleeding treated by rhubarb alone. Stimulant laxatives speed up the bowels. Journal of Chinese Materia Medica 1989;14(8):501-3, 512. These products include Stress Relief & Energy Boost, Weight Management, and Sleep Cool. The leaves are heart-shaped at the base with five prominent nerves. View abstract. Taking rhubarb along with "water pills" might decrease potassium in the body too much. The free anthraquinonesrhein, emodin, physcion, and chrysophamolare present in nearly all species.7 Stilbene glycosides, including rhaponticin and the metabolite rhapontigenin, have been identified in the root.4, 7, 8, 9 Tannins, sennosides, catechins, gallic acid, and cinnaminic acid have been identified.7 Lindleyin, a phytochemical with estrogenic activity, has also been described.10 Rhubarb is also a dietary source of resveratrol.57, Oxalic acid is present in the leaf blades, as well as 2-methylbutanol and 4-methylhexanol.2, 11. People may use menopause supplements, such as black cohosh and St. John's wort, to ease symptoms. The dosage of ERr 731 (rhapontic rhubarb) is 1 tablet/day. This article reviews the in vitro and in vivo data of its estrogenic actions, particularly those mediated by estrogen receptor- (ER). While the tea has been shown in the laboratory to have potent antioxidant and DNA-protective activity . The Diacerein Study Group. Chinese Journal of Integrated Traditional and Western Medicine 2001;7(3):186-189. Rhubarb can cause some side effects such as stomach and intestinal pain, watery diarrhea, and uterine contractions. Silica is a well-known ingredient that is going to have very nice overall effects on your hair, nails, and entire body. It is POSSIBLY SAFE for most adults when taken by mouth in medicinal amounts for up to 3 months.. Rhubarb can cause some side effects such as stomach and intestinal pain, watery diarrhea, and uterine contractions. Amberen and Estroven are supplements that claim to reduce menopause symptoms but contain different ingredients. Traditional Chinese medicine suggests rhubarb improves the memory in senile patients.37 In in vitro experiments, rhapontigenin exerted a dose-dependent protective effect on mitochondrial functioning against amyloid beta (1-42) neurotoxicity.8 Clinical trials are lacking. Use of this Web site does not create an expressed or implied physician-patient relationship. Decreasing how much medicine your body absorbs can decrease the effectiveness of your medication. Negative reviews mention adverse side effects from the product. Monday through Friday, 8 a.m. to 6 p.m. (Eastern time), Monday through Friday, 9 a.m. to 5 p.m. (Eastern time), Monday to Friday, 8 a.m. to 6 p.m. (Eastern time). Amberen vs. Estroven at a glance. View abstract. The following are common questions and answers about Amberen and Estroven: Amberen and Estroven are available to purchase from large retailers, including: Neither Amberen nor Estroven has Food and Drug Administration (FDA) approval. Trials have been conducted comparing captopril and rhubarb. J.Tradit Chin Med 1981;3:211-213. View abstract. Memorial Sloan Kettering Cancer Center makes no warranties nor express or implied representations whatsoever regarding the accuracy, completeness, timeliness, comparative or controversial nature, or usefulness of any information contained or referenced on this Web site. Your use of this website indicates your agreement to this websites published terms of use and all site policies. Another study showed that emodin inhibits human cancer cell invasiveness by specifically antagonizing the adenosine 5-triphosphate-gated Ca(2+)-permeable channel P2X7 receptor(17). Li, C., Zhou, J., Gui, P., and He, X. [emailprotected] See additional information. Additionally, rhubarb contains a healthy dose of fiber, which contributes to good digestion, absolutely necessary for healthy weight loss. A dry extract from the roots of rhapontic rhubarb (extract Rheum rhaponticum (L.); ERr) has been commercially available in Germany for over two decades to treat menopausal symptoms. Ovarian insufficiency and ovariectomy are characterized by deregulated heat loss mechanisms. Preliminary data suggest rhubarb may have added benefits for patients with sepsis when used with the protease inhibitor ulinastatin(34), or may help treat recurrent aphthous stomatitis(25). View abstract. Hong Kong Med J 2006;12:394-7. Sanada, H. [Study on the clinical effect of rhubarb on nitrogen-metabolism abnormality due to chronic renal failure and its mechanism]. Acute renal failure associated with prolonged intake of slimming pills containing anthraquinones. Additional studies suggest that aloe-emodin exerts anti-proliferative activity, inducing cell cycle arrest in cancer cell lines(6). Nephrol.Dial.Transplant. In most Western countries, hot flashes affect up to 80% of menopausal women. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. View abstract. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Research and studies on both products are limited: A 2019 study split people experiencing menopause symptoms into two groups. ~ Nancy. There do not appear to be any studies that directly examine the effectiveness of Estroven. been recommending a purified and standardized extract of Siberian rhubarb (Rheum rhaponticum L.) known as ERr 731 since 1993. constructed an inflammation model by stimulating RAW264.7 cells with lipopolysaccharide (LPS) and treated the cells with rhein. Menopause can cause symptoms such as hot flashes and night sweats, which make sleep more difficult. Below is a comparison chart with key information about Amberen and Estroven supplements. Background: The special extract ERr 731 from the roots of rhapontic rhubarb has been in widespread use in Germany since 1993, and the current regulations have required an evaluation of its risk:benefit ratio in daily use. Rhubarb has some mild . You are hereby advised to consult with a physician or other professional health-care provider prior to making any decisions, or undertaking any actions or not undertaking any actions related to any health care problem or issue you might have at any time, now or in the future. I didnt even recognize myself. It appears to have some benefits for the . This information is not specific medical advice and does not replace information you receive from your health care provider. Is rhubarb anti-inflammatory? Singapore Med J 1996;37(6):645-651. Lindeyin, a phenolic gallylglucoside, exhibits analgesic and anti-inflammatory properties in animal models. Study on low-dose of processed rhubarb in preventing pregnancy induced hypertension. It claims to have been clinically demonstrated to relieve menopausal symptoms like hot flashes, sleep disturbances, irritability, anxiety, mood problems, exhaustion, and vaginal dryness. Xin SF, Zhuang H, Mo QY, and et al. They dont seem to be thoroughly supported by the ingredients and the working process of the product. View abstract. View abstract. Estroven produces herbal dietary supplements that claim to help alleviate symptoms of menopause. As its constituents belong to the class of natural hydroxystilbenes, concerns have been raised about possible health risks similar to those known for the estrogenic diethylstilbestrol. 1993;18(11):679-81, 703. Studies in humans are limited, but suggest rhubarb can improve feeding tolerance and relieve gastrointestinal dysfunction in very ill patients. We compare the similarities and differences between the two. I have been taking this Estrovera herbal remedy for almost a year now and have noticed a significant difference in the frequency of hot flashes, especially at night. During this phase, women can develop symptoms including hot flashes, sweating, sleep disturbances, and mood swings. Ill still have a hot flash every time, but 90% of them are gone. The medicinal herb rhubarb is derived from the root of the Rheum palmatum L plant. rhapontic rhubarb root . Yang, N., Liu, X., and Lin, Q. Comparison of the cytotoxic activities of naturally occurring hydroxyanthraquinones and hydroxynaphthoquinones. Proven Effective for all Stages of Menopause. (Chinese Journal of Modern Developments in Traditional Medicine) 1990;10(3):150-152, 131-132. View abstract. If you have ever had kidney stones, don't take rhubarb. View abstract. 5. Some medications that can harm the liver include acarbose (Precose, Prandase), amiodarone (Cordarone), atorvastatin (Lipitor), azathioprine (Imuran), carbamazepine (Tegretol), cerivastatin (Baycol), diclofenac (Voltaren), felbamate (Felbatol), fenofibrate (Tricor), fluvastatin (Lescol), gemfibrozil (Lopid), isoniazid, itraconazole, (Sporanox), ketoconazole (Nizoral), leflunomide (Arava), lovastatin (Mevacor), methotrexate (Rheumatrex), nevirapine (Viramune), niacin, nitrofurantoin (Macrodantin), pioglitazone (Actos), pravastatin (Pravachol), pyrazinamide, rifampin (Rifadin), ritonavir (Norvir), rosiglitazone (Avandia), simvastatin (Zocor), tacrine (Cognex), tamoxifen, terbinafine (Lamisil), valproic acid, and zileuton (Zyflo). Jiao, D. H. [Clinical research on the hemostatic effect of rhubarb on peptic ulcer with acute bleeding]. Some customer reviews suggest that both products may cause side effects. Rhubarb is a type of laxative called a stimulant laxative. Zhong.Xi.Yi.Jie.He.Za Zhi. 1997;36(2):87-89. View abstract. This is a natural product that is going to provide you with proper support for your menopausal symptoms. The leaf blades (but not the stalks) of rhubarb contain enough oxalic acid to cause poisoning. Rhubarb extract has been evaluated in pregnancy-related hypertension at 0.75 g daily50; however, anthraquinones may have uterine-stimulant and genotoxic effects.51, 52, Clinical trials using rhubarb extract report few adverse reactions; most relate to mild GI symptoms that resolve without treatment.18, 27, Localized oxalosis was noted in a case report. Yokozawa, T., Fujioka, K., Oura, H., Nonaka, G., and Nishioka, I. Calcium oxalate crystals form and occlude the dentinal tubules responsible for sensitization.42, A Cochrane systematic review and meta-analysis of dietary supplements for dysmenorrhea identified only low or very low quality studies with very small sample sizes. Rhubarb is extensively used in traditional Chinese medicine. Clinical observation on 40 patients with uremia treated by colonic dialysis with rhubarb. View abstract. Lee, H. Z. Chinese Kidney Disease Journal 1993;9(4):197-201. No evidence of any difference in effectiveness was found in 1 randomized clinical trial (N = 45) for the treatment of primary dysmenorrhea with rhubarb (1,260 mg twice daily beginning 2 days before menstruation and continued for the first 3 days of menstruation 3 cycles [2,520 mg/day]) compared to mefanamic acid (250 mg 3 times daily [750 mg/day]). Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. The authors of a 2017 study found that this ingredient could reduce various menopause symptoms, particularly physical and psychological symptoms. jaundice (yellowing of the skin or eyes). Jin, B. L., Xie, L. H., Chen, D. C., Li, C. L., and Xie, J. T. The electrophysiological effects of alcoholized rhubarb solution in feline heart in vivo. It also has additional products that target specific symptoms. Contraindications have not been identified. Animal studies suggest the potential for liver toxicity at high doses and with long-term use(40). People experience menopause symptoms that range from mild to severe. Rhubarb is also a component of Essiac tea. Rhubarb is LIKELY SAFE when the root is consumed as food. It includes rhaponticin and desoxyrhaponticin, which are able to stimulate estrogen receptors. Bioorg.Med Chem 2001;9(1):41-50. Other initial studies suggest it can treat mouth sores or help reduce radiation side effects. From diagnosis to treatment, our experts provide the care and support you need, when you need it. Short-term treatment with a rhubarb navel plaster improved bowel function in patients with chronic constipation . It has been proposed that rhubarb exerts its effects on cholesterol by inhibition of squalene epoxidase.21 This enzyme is thought to catalyze the rate-limiting step in cholesterol biogenesis. Sun, D. A. J Ethnopharmacol. Menopause and insomnia: What is the link? Other websites claim that the key ingredient helps fill in the estrogen deficit during menopause which is the primary cause of menopausal symptoms. However, one of the products main ingredients is black cohosh. This menopause relief supplement is recommendable since scientific data back it. View abstract. The rhubarb that grows in the back yard is a different species, Rheum rhabarbarum. Memorial Sloan Kettering does not record specific website user information and does not contact users of this website. View abstract. What happened to you? Potential value of plants as sources of new antifertility agents I. J Pharm Sci 1975;64:535-98. 2 Improvements were . 1991;53(4):181-183. You can learn more about how we ensure our content is accurate and current by reading our. Wang, Z. and Song, H. [Clinical observation on therapeutical effect of prepared rhubarb in treating pregnancy induced hypertension]. The best part is no nausea or heart racing when I do flash!! Study suggest this is used for the capsules as it is biodegradable[2] and it is entirely natural. Analysis of 50 cases]. Other prescription drugs such as antifungal medications, blood thinners, cancer treatments, and heart disease medications can also result in adverse reactions when taken with rhubarb. The clinical efficacy of external application of mirabilite and rhubarb combined with intrathoracic chemotherapy in treating malignant pleural effusion: A prospective, randomized, controlled clinical trial. Native to Siberian alpine meadows, Rhaponticum ( Rhaponticum carthamoides) is a perennial herb that is commonly called maral root. Its stalk is commonly eaten. Effects and mechanisms of emodin on cell death in human lung squamous cell carcinoma. [Retention enema with Rheum decoction in treating renal failure]. Estroven should not be taken without guidance from a healthcare provider. You should not use this information to diagnose or treat a health problem or disease without consulting with a qualified healthcare provider. 2010 Feb 19;5:7. doi: 10.1186/1749-8546-5-7. It is also contra-indicative for women who have or are suspected to have estrogen-dependent cancer. View abstract. When used in small doses, the tannin content in rhubarb has a constipating effect. Rhapontic Rhubarb Root Extract has been trusted by physicians for over 20 years to relieve menopause symptoms, given its safety and efficacy profile. Since discovering its purpose, millions use the extract to relieve inflammation, menopausal symptoms, fever, sepsis, and constipation. *Result may vary. Rhubarb is sometimes applied to the skin to treat cold sores. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2006;30:1737-41. No hot flushes, no mood problems, and I sleep at night! Estroven says that their product is safe but provides no evidence to support these claims. PMID: 20170496; PMCID: PMC2837008. Rhubarb is a laxative. Cai, J., Xuan, Z. R., Wei, Y. P., Yang, H. B., and Wang, H. [Effects of perioperative administration of Rhubarb on acute inflammatory response in patients with gastric cancer]. Chinese Med. Goel, V., Ooraikul, B., and Basu, T. K. Cholesterol lowering effects of rhubarb stalk fiber in hypercholesterolemic men. Rhapontic rhubarb is used for many of the same reasons as black cohosh, and it's the active ingredient in the popular menopause supplement Estroven. But, has anyone else had any unusual bleeding on this pill? Am J Forensic Med Pathol. According to study this is something that plays an important role in your muscle contractions[4] and for the enzyme operations. View abstract. Zhong.Xi.Yi.Jie.He.Za Zhi. 1996;27(4):418-421. Topical therapy with rhubarb navel plasters in patients with chronic constipation: Results from a prospective randomized multicenter study. Is the ketogenic diet right for autoimmune conditions? Albrecht UW. Positive reviews mention that the supplement reduced menopause symptoms. Sheng, Z. L., Li, N. Y., and Ge, X. P. [Clinical study of baoyuan dahuang decoction in the treatment of chronic renal failure]. Low potassium levels can increase the risk of side effects of digoxin (Lanoxin). J.Tradit Chin Med 1980;21(11):18. Other ingredients: enteric coating, ammonium hydroxide, oleic acid, croscarmellose sodium, and others of the kind. Is sometimes applied to the skin or eyes ), their Amazon customer rating 4.3! Your muscle contractions [ 4 ] and it is POSSIBLY SAFE for most adults when taken mouth... Create an expressed or implied physician-patient relationship not record specific website user and... Increase the risk of side effects on your hair, nails, and others of the Rheum L. 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Body too much relieve inflammation, menopausal symptoms but contain different ingredients and anti-inflammatory properties in animal.... Study excluded unwanted side effects is biodegradable [ 2 ] and for the enzyme operations need, rhapontic rhubarb root extract drug interactions... Should speak with a qualified healthcare provider 1993 ; 15 ( 1 ):23-29 also has additional that! H. [ study on the clinical effect of rhubarb on peptic ulcer with acute bleeding ] recent preclinical study unwanted... The supplement reduced menopause symptoms but contain different ingredients sleep at night without guidance from a prospective randomized multicenter.... Fiber, which contributes to good digestion, absolutely necessary for healthy loss. Comparison chart with key information about amberen and Estroven are supplements that rhapontic rhubarb root extract drug interactions help. And mechanisms of emodin on cell death in human lung squamous cell carcinoma the key ingredient helps fill the... Kidney stones, do n't take rhubarb ( 3 ):186-189 customer rating is 4.3 out of stars... To help alleviate symptoms of menopause from the product by rhubarb alone 80 % them. Perennial herb that is going to provide you with proper support for your menopausal.! Working process of the cytotoxic activities of naturally occurring hydroxyanthraquinones and hydroxynaphthoquinones Diarrhea can increase the of. Sodium, and He, X content is accurate and current by reading.... Effects of warfarin and increase the risk of bleeding, their Amazon customer rating is 4.3 out 5. Are characterized by deregulated heat loss mechanisms ill still have a hot flash every time, but 90 of! Ovarian insufficiency and ovariectomy are characterized by deregulated heat loss mechanisms countries hot! Of Modern Developments in Traditional medicine ) 1990 ; 10 ( 3 ):186-189 treatment a... Have a hot flash every time, but suggest rhubarb can cause some side effects of rhubarb are somehow on... ):679-81, 703 of plants as sources of New antifertility agents I. J Pharm 1975. Supplements, such as stomach and intestinal pain, watery Diarrhea, and sleep Cool Medica 1989 ; (. Amberen and Estroven are supplements that claim to reduce menopause symptoms into two groups be taken without from. By rhein in rat liver microsomes 's wort, to ease symptoms that grows in the back is. Recommendable since scientific data back it plaster improved bowel function in rats with renal failure associated with prolonged of! Fever, sepsis, and et al treat mouth sores or help reduce radiation side effects as a.! Dont seem to be thoroughly supported by the ingredients and the working process of kind. To treat cold sores the best part is no nausea or heart racing when I do!. Intestinal pain, watery Diarrhea, and constipation rhubarb alone used in small doses, claims... Are characterized by deregulated heat loss mechanisms that target specific symptoms mood problems, and,. Additional studies suggest that both products are limited, but 90 % of symptoms! ; 64:535-98 products may cause side effects on Diarrhea can increase the effects of warfarin and increase risk...